Current Issue : January-March Volume : 2018 Issue Number : 1 Articles : 4 Articles
Topical delivery of clobetasole propionate (CP) offers several formulation related problems due to poor water solubility and photo degradation property. In the present investigation, topical gel of CP was formulated using acrylamide/ sodium acryloyldimethyl taurate copolymer (SEPINEOââ??¢ P 600) as a gelling agent and evaluated with respect to different physicochemical parameters such as pH, viscosity, bio-adhesivity, spreadability, in-vitro drug release and photo stability. Permeation of CP gel was studied using freshly excised pig ear skin for 24 h. The cumulative permeation of drug through excised rat skin was 3.0Ã?±1.2 mg cm-2 with the corresponding flux value of 0.24Ã?±0.09 mg cm-2 h-1. The in-vitro release studies showed 101.43Ã?±1.12 % drug release over 10 h. The selected formulation was found to be effective with respect to percent drug content, permeation characteristics, pH, viscosity and photostability. Therefore, CP gel could be very promising alternative for the topical drug delivery....
Topical agents are widely used to treat skin conditions, with the occurrence of bacterial resistance to antibiotics and controversy regarding the use of topical antiseptics persists, man turned to his prehistory and found literally thousands of phytochemicals, which inhibit different types of microorganisms. The specific aim of the present article was to prepare and evaluate antimicrobial herbal gel. The first step was the selection of plant parts according to long history of use, references in Ayurvedic literature, leaves extracts of Nyctanthes arbor-tristis. Plant materials were dried in the dark at room temperature. Ethanol was used as solvent for extraction by maceration procedure. These extracts were subjected to antimicrobial activity by agar diffusion method to detect potential antimicrobial activity against P. aeruginosa, E. coli and Bacillus substilis, some common human skin infecting pathogens. The results showed that ethanolic extracts of Nyctanthes arbor-tristis leaves posses strong in-vitro antibacterial activity. Each formulation was characterized in terms of viscosity, pH, extrudability, spreadability, homogenicity, antimicrobial activity compared with that of standard formulation. Among all the prepared formulations F2, F4 were regarded as the best formulations....
Sustained Release (SR) drug delivery system significantly improve therapeutic efficacy of a drug. Drug release retarding polymers are the key performer in such systems. Cimetidine is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for treatment of acid-peptic disease and heartburn. Cimetidine has been linked to rare instances of clinically apparent acute liver injury. A commonly used agent for treatment of duodenal and gastric ulcer and gastroesophageal reflux disease. Mucoadhesive microcapsule were prepared by orifice ionic gelation method with polymers combinations such as carbopol and HPMC, carbopol and xanthan gum, carbopol and ethyl cellulose, carbopol and guar gum, against carbopol only, in the drug-polymer ratio of 1:3 w/w using cimetidine as model drug. The average particle size of the formulation F3 was found to be 739.2 �µm. The %yield of the prepared microcapsules was found to be 88.5 % for formulation F3, which is regarded as best formulation. Among all the prepared formulations formulation F3 was found to be the best formulation with a % drug release of 92.3%. The pattern of drug release was found to be zero-order kinetics....
Colon-targeted drug delivery has potential to deliver bioactive agents for the treatment of a variety of colonic diseases and to deliver proteins and peptides to the colon for their systemic absorption. Various strategies, currently available to target the release of drugs to colon, include formation of prodrug, coating of pH-sensitive polymers, use of colon-specific biodegradable polymers, timed-released systems, osmotic systems and pressure-controlled drug delivery systems. Among the different approaches to achieve targeted drug release to the colon, is by using pectin and its-derived matrices which are now being examined and tested. Pectin is intact in the upper gastrointestinal tract but degraded by colonic microï¬â??ora. The composition of colonic microï¬â??ora remains relatively consistent across a diverse human population. Thus, pectin drug carriers provide promising potential for colon-targeted drug delivery. This paper reviews pectin-derived formulations for specific drug delivery. Subjects reviewed includes gelation of pectin, salt of pectin, amidated pectins, pectin combination with other polymers, different formulation techniques and methods to evaluate release kinetics of incorporated drugs. Various polysaccharides have been investigated for colon specific drug release. The most favorable property of these materials is their approval as pharmaceutical excipients....
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